Publications
2022-2023
Beta-Caryophyllene Inhibits Oxaliplatin-Induced Peripheral Neuropathy in Mice: Role of Cannabinoid Type 2 Receptors, Oxidative Stress and Neuroinflammation. Agnes, J.P.; dos Santos, B.; das Neves, R.N.; Luciano, V.M.M.; Benvenutti, L.; Goldoni, F.C.; Schran, R.G.; Santin, J.R.; Quintão, N.L.M.; Zanotto-Filho, A. Antioxidants 2023, 12, 1893. https://doi.org/ 10.3390/antiox12101893
Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Falchetti M, Delgobo M, Zancanaro H, Almeida K, das Neves RN, Dos Santos B, Stefanes NM, Bishop A, Santos-Silva MC, Zanotto-Filho A. Comput Biol Med. 2023 Nov 25;152:106347. doi: 10.1016/j.compbiomed.2022.106347
2020-2021
Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer. Delgobo M, Gonçalves RM, Delazeri MA, Falchetti M, Zandoná A, Nascimento das Neves R, Almeida K, Fagundes AC, Gelain DP, Fracasso JI, Macêdo GB, Priori L, Bassani N, Bishop AJR, Forcelini CM, Moreira JCF, Zanotto-Filho A. Free Radicals Biol Med. 2021;177:58-71. doi: 10.1016/j.freeradbiomed.2021.10.020. PMID: 34673143
Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation. Agnes JP, Santos VWD, das Neves RN, Gonçalves RM, Delgobo M, Girardi CS, Lückemeyer DD, Ferreira MA, Macedo-Júnior SJ, Lopes SC, Spiller F, Gelain DP, Moreira JCF, Prediger RD, Ferreira J, Zanotto-Filho A. Journal of Pain. 2021 Mar 24:S1526-5900(21)00183-8. doi: 10.1016/j.jpain.2021.03.142.
COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. Gonçalves RM, Delgobo M, Agnes JP, das Neves RN, Falchetti M, Casagrande T, Garcia APV, Vieira TC, Somensi N, Bruxel MA, Mendes DAGB, Rafacho A, Báfica A, Gelain DP, Moreira JCF, Cassali GD, Bishop AJR, Zanotto-Filho A. Cancer Letters. 2021 doi: 10.1016/j.canlet.2021.01.003.
Classification algorithms applied to blood-based transcriptome meta-analysis to predict idiopathic Parkinson’s disease. Marcelo Falchetti, Rui Daniel Prediger, Alfeu Zanotto-Filho. Computers Biol Med. 2020, 124: 103925-103935, doi: 10.1016/j.compbiomed.2020.103925
Efficient identification of novel anti-glioma lead compounds by machine learning models. Neves BJ, Agnes JP, Gomes MDN, Henriques Donza MR, Gonçalves RM, Delgobo M, Ribeiro de Souza Neto L, Senger MR, Silva-Junior FP, Ferreira SB, Zanotto-Filho A, Andrade CH. Eur J Med Chem. 2020, 19;189:111981. doi: 10.1016/j.ejmech.2019.111981. PMID:31978780
2017-2019
Late autophagy inhibitor chloroquine improves efficacy of the histone deacetylase inhibitor SAHA and temozolomide in gliomas. Gonçalves RM, Agnes JP, Delgobo M, de Souza PO, Thomé MP, Heimfarth L, Lenz G, Moreira JCF, Zanotto-Filho A. Biochem Pharmacol. 2019;163:440-450. doi: 10.1016/j.bcp.2019.03.015
Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells. Zanotto-Filho A, Rajamanickam S, Loranc E, Masamsetti VP, Gorthi A, Romero JC, Tonapi S, Gonçalves RM, Reddick RL, Benavides R, Kuhn J, Chen Y, Bishop AJR. Cancer Letters. 2018 Jul 1;425:101-115. doi: 10.1016/j.canlet.2018.03.037.
N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. Delgobo M, Agnes JP, Gonçalves RM, Dos Santos VW, Parisotto EB, Zamoner A, Zanotto-Filho A. J Nutritional Biochem. 2019 May;67:190-200. doi: 10.1016/j.jnutbio.2019.02.012
Inflammatory landscape of human brain tumors reveals an NFκB dependent cytokine pathway associated with mesenchymal glioblastoma. Zanotto-Filho A, Gonçalves RM, Klafke K, de Souza PO, Dillenburg FC, Carro L, Gelain DP, Moreira JC. Cancer Letters. 2017;390:176-187. doi: 10.1016/j.canlet.2016.12.015.
2016-2017
Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human. Zanotto-Filho A, Dashnamoorthy R, Loranc E, de Souza LH, Moreira JC, Suresh U, Chen Y, Bishop AJ. PLoS One. 2016 Apr 21;11(4):e0153970. doi: 10.1371/journal.pone.0153970. eCollection 2016.
Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis. Zanotto-Filho A, Masamsetti VP, Loranc E, Tonapi SS, Gorthi A, Bernard X, Gonçalves RM, Moreira JC, Chen Y, Bishop AJ. Mol Cancer Therapeutics. 2016 Dec;15(12):3000-3014